coeliac disease, mucosal change and iel: doing what counts the best

نویسندگان

michael n marsh

چکیده

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Coeliac disease, mucosal change and IEL: doing what counts the best.

There has been a flurry of activity in GHFBB arising from my classification (1), and I am flattered that the editors have now asked me for an overview. Readers should note that the flurry originated from a recent paper (2) in which we revealed the redundancy of Oberhuber's re-classification of the Marsh III coeliac lesion. First, we indicated that there is no structural basis for his assertion....

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Mucosal healing and mortality in coeliac disease.

BACKGROUND Coeliac disease (CD), characterised by the presence of villous atrophy (VA) in the small intestine, is associated with increased mortality, but it is unknown if mortality is influenced by mucosal recovery. AIMS To determine whether persistent VA is associated with mortality in CD. METHODS Through biopsy reports from all pathology departments (n = 28) in Sweden, we identified 7648...

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Doing what we do best, only better

As current editor-in-chief and executive editor for the Journal of Cell Biology, we are writing to describe our shared vision for the journal: To enable the swift and painless publication of advances and thought-provoking ideas in a range of fields that inform cell biology, and to promote this high-quality work as broadly as possible in our community. Throughout 2015, we celebrated the 60th ann...

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ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation

OBJECTIVES Counting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive 'normal' IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucos...

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Mucosal ulceration and mesenteric lymphadenopathy in coeliac disease.

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Mucosal secretory IgA and secretory piece in adult coeliac disease.

Immunofluorescence studies with specific antisera to secretory IgA (11S IgA) and secretory piece were carried out on the jejunal mucosa of nine patients with adult coeliac disease (treated and untreated). The results were compared with those obtained in four normal patients and in four patients with local and systemic IgA (7S) deficiency. 11S IgA and secretory piece were localized to the upper ...

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عنوان ژورنال:
gastroenterology and hepatology from bed to bench

جلد ۱، شماره ۹، صفحات ۲۰۱۶-۹

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